As global populations age, the incidence of seizures and epilepsy rises sharply—particularly after age 65. Yet the mechanisms that make the aging brain more vulnerable to abnormal electrical activity remain poorly understood. A growing body of evidence points toward dysfunction in one crucial system: the neurovascular unit (NVU).

By understanding - and modifying - the biology of aging, we have the chance to: ✔ prevent disease before it starts✔ slow or reverse early damage✔ develop therapies that work across conditions✔ extend cognitive healthspan, not just lifespan✔ rethink dementia as something we can influence, not simply endure.

Aging doesn’t cause neurodegeneration in a direct, linear way. Rather, it gradually weakens the systems that normally protect the brain.